Bcl-2 family members make different contributions to cell death in hypoxia and/or hyperoxia in rat cerebral cortex.

@article{Hu2003Bcl2FM,
  title={Bcl-2 family members make different contributions to cell death in hypoxia and/or hyperoxia in rat cerebral cortex.},
  author={Xiaoming Hu and Jingxin Qiu and Marjorie R. Grafe and Harriett Charmaine Rea and David Keith Rassin and Jose Regino Perez-Polo},
  journal={International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience},
  year={2003},
  volume={21 7},
  pages={371-7}
}
Hypoxic brain injury during fetal or neonatal development leads to damaged immature neurons and can result in cognitive or behavioral dysfunction. Hyperoxia therapy (treatment with oxygen) is commonly applied to infants with signs of perinatal hypoxia-anoxia. Both hypoxia and hyperoxia have been shown to result in apoptosis in the brains of rats in several animal models. One determinant of cellular commitment to cell death is the differential expression of the Bcl-2 family of proteins in… CONTINUE READING