Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1.

Abstract

The Bcl-2 family of proteins regulates apoptosis, the cell death program triggered by activation of certain proteases (caspases). An attractive model for how Bcl-2 and its closest relatives prevent caspase activation is that they bind to and inactivate an adaptor protein required for procaspase processing. That model has been supported by reports that… (More)

Topics

Cite this paper

@article{Moriishi1999Bcl2FM, title={Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1.}, author={Kohji Moriishi and D. C. Huang and Shelly Cory and J. M. Adams}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1999}, volume={96 17}, pages={9683-8} }