Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity

@article{Youn2005Bcl2ES,
  title={Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity},
  author={Cha Kyung Youn and Hyun-Ju Cho and Soo-Hyun Kim and Hong-Beum Kim and Mi-hwa Kim and In Youb Chang and Jung-Sup Lee and Myung Hee Chung and Kyung-soo Hahm and Ho Jin You},
  journal={Nature Cell Biology},
  year={2005},
  volume={7},
  pages={137-147}
}
Bcl-2 stimulates mutagenesis after the exposure of cells to DNA-damaging agents. However, the biological mechanisms of Bcl-2-mediated mutagenesis have remained largely obscure. Here we demonstrate that the Bcl-2-mediated suppression of hMSH2 expression results in a reduced cellular capacity to repair mismatches. The pathway linking Bcl-2 expression to the suppression of mismatch repair (MMR) activity involves the hypophosphorylation of pRb, and then the enhancement of the E2F–pRb complex. This… 
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