Bcl-2 expression prevents activation of the ICE protease cascade.

  title={Bcl-2 expression prevents activation of the ICE protease cascade.},
  author={Shigeomi Shimizu and Yutaka Eguchi and Wataru Kamiike and Hikaru Matsuda and Yoshihide Tsujimoto},
  volume={12 11},
The Bcl-2 family and the ICE family of cysteine proteases play important roles in regulating cell death. We show here that induction of cell death by a Ca2+ ionophore or hypoxia results in increased levels and activity of active ICE(-like) proteases and the subsequent activation of CPP32/Yama(-like) proteases, and that inhibition of these protease activities reduces the extent of cell death. Overexpression of the anti-apoptotic proteins Bcl-2 or Bcl-xL inhibits the cell death and the activation… CONTINUE READING

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