Bcl-2 expression in acute myelogenous leukemia: the relation to myeloid antigen expression and response to therapy in Iranian patients.

@article{Daneshbod2005Bcl2EI,
  title={Bcl-2 expression in acute myelogenous leukemia: the relation to myeloid antigen expression and response to therapy in Iranian patients.},
  author={Yahya Daneshbod and Zahra Amirghofran and Seyed Ziyaodin Tabei},
  journal={Neoplasma},
  year={2005},
  volume={52 2},
  pages={109-14}
}
Product of Bcl-2 gene prolongs survival of hematopoietic cells by inhibition of programmed cell death. The aim of this study is to examine the expression of the bcl-2 protein in a group of patients with AML and its relation to clinical features and response to therapy. Slides from the bone marrow or peripheral blood of 70 patients with AML were assessed for the expression of bcl-2 by immunocytochemistry. The expression of myeloid and non-lineage associated markers was detected by indirect… CONTINUE READING