Bcl-2-dependent modulation of swelling-activated Cl- current and ClC-3 expression in human prostate cancer epithelial cells.

@article{Lemonnier2004Bcl2dependentMO,
  title={Bcl-2-dependent modulation of swelling-activated Cl- current and ClC-3 expression in human prostate cancer epithelial cells.},
  author={Lo{\"i}c Lemonnier and Yaroslav Shuba and Alexandre Cr{\'e}pin and Morad Roudbaraki and Christian Slomianny and Brigitte Mauroy and Bernd Nilius and Natalia Prevarskaya and Roman Skryma},
  journal={Cancer research},
  year={2004},
  volume={64 14},
  pages={4841-8}
}
Cell shrinkage is an integral part of apoptosis. However, intimate mechanisms linking apoptotic events to the alterations in cell volume homeostasis remain poorly elucidated. We investigated how overexpression of Bcl-2 oncoprotein, a key antiapoptotic regulator, in lymph node carcinoma of the prostate (LNCaP) prostate cancer epithelial cells interferes with the volume-regulated anion channel (VRAC), a major determinant of regulatory volume decrease. Bcl-2 overexpression resulted in the doubling… CONTINUE READING