Bcl-2 decreases voltage-gated K+ channel activity and enhances survival in vascular smooth muscle cells.

@article{Ekhterae2001Bcl2DV,
  title={Bcl-2 decreases voltage-gated K+ channel activity and enhances survival in vascular smooth muscle cells.},
  author={Daryoush Ekhterae and Oleksandr Platoshyn and Stefanie Krick and Ying Di Yu and Sharon S. McDaniel and Jason X-J Yuan},
  journal={American journal of physiology. Cell physiology},
  year={2001},
  volume={281 1},
  pages={C157-65}
}
Cell shrinkage is an incipient hallmark of apoptosis in a variety of cell types. The apoptotic volume decrease has been demonstrated to attribute, in part, to K+ efflux; blockade of plasmalemmal K+ channels inhibits the apoptotic volume decrease and attenuates apoptosis. Using combined approaches of gene transfection, single-cell PCR, patch clamp, and fluorescence microscopy, we examined whether overexpression of Bcl-2, an anti-apoptotic oncoprotein, inhibits apoptosis in pulmonary artery… CONTINUE READING

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A primary role for K1 and Na1 efflux in the activation of apoptosis

  • CD Bortner, Hughes FM, JA Cidlowski
  • J Biol Chem
  • 1997
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