Bcl-2 and apoptosis in chronic lymphocytic leukemia.

  title={Bcl-2 and apoptosis in chronic lymphocytic leukemia.},
  author={Aaron David Schimmer and Irene Munk-Pedersen and Mark D Minden and John C. Reed},
  journal={Current treatment options in oncology},
  volume={4 3},
The Bcl-2 family of pro- and antiapoptotic proteins are key regulators of the apoptosis cascade and the mitochondrial-mediated pathway of caspase activation. Of this family, Bcl-2 was the first identified and remains the best characterized. Aberrant expression of Bcl-2 is common in chronic lymphocytic leukemia (CLL) and is associated with poor response to chemotherapy and decreased overall survival. Bcl-2 is an attractive target for novel therapeutic agents. Antisense oligonucleotides directed… CONTINUE READING

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