Bcl-2 accelerates multistep prostate carcinogenesis in vivo

@article{Bruckheimer2000Bcl2AM,
  title={Bcl-2 accelerates multistep prostate carcinogenesis in vivo},
  author={Elizabeth M Bruckheimer and Shawn Brisbay and Dennis J Johnson and Jeffrey R Gingrich and Norman Greenberg and Timothy J. McDonnell},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={5251-5258}
}
  • Elizabeth M Bruckheimer, Shawn Brisbay, +3 authors Timothy J. McDonnell
  • Published in Oncogene 2000
  • Medicine, Biology
  • The impact of bcl-2 proto-oncogene expression on the pathogenesis and progression of prostate cancer was examined in a transgenic mouse model. Probasin-bcl-2 transgenic mice were crossed with TRAMP (TRansgenic Adenocarcinoma Mouse Prostate) mice that express the SV40 early genes (T/t antigens) under probasin control. Prostate size, cell proliferation, apoptosis, and the incidence and latency of tumor formation were evaluated. The double transgenic, probasin-bcl-2 X TRAMP F1 (BxT) mice exhibited… CONTINUE READING

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