Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

@article{Pattingre2005Bcl2AP,
  title={Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy},
  author={Sophie Pattingre and Amina Tassa and Xueping Qu and Rita Garuti and Xiao Huan Liang and Noboru Mizushima and Milton Packer and Michael H. Schneider and Beth Levine},
  journal={Cell},
  year={2005},
  volume={122},
  pages={927-939}
}
Apoptosis and autophagy are both tightly regulated biological processes that play a central role in tissue homeostasis, development, and disease. The anti-apoptotic protein, Bcl-2, interacts with the evolutionarily conserved autophagy protein, Beclin 1. However, little is known about the functional significance of this interaction. Here, we show that wild-type Bcl-2 antiapoptotic proteins, but not Beclin 1 binding defective mutants of Bcl-2, inhibit Beclin 1-dependent autophagy in yeast and… CONTINUE READING
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