Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance.

Abstract

The bcl-2 gene is overexpressed in the absence of gene rearrangements in most cases of B-cell chronic lymphocytic leukaemia (B-CLL) and the proto-oncogene product Bcl-2 has been shown to be a regulator of apoptosis. The activity of this protein is opposed by Bax, a homologous protein that accelerates the rate of cell death. B-lymphocyte Bcl-2 and Bax… (More)
DOI: 10.1038/bjc.1997.487

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@article{Pepper1997Bcl2BaxRI, title={Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance.}, author={Chris Pepper and Terry Hoy and Douglas P. Bentley}, journal={British Journal of Cancer}, year={1997}, volume={76}, pages={935 - 938} }