Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish.

@article{MaySimera2010Bbs8TW,
  title={Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish.},
  author={Helen Louise May-Simera and Masatake Kai and Victor Perez Hernandez and Daniel P S Osborn and Masazumi Tada and Philip L. Beales},
  journal={Developmental biology},
  year={2010},
  volume={345 2},
  pages={215-25}
}
Laterality defects such as situs inversus are not uncommonly encountered in humans, either in isolation or as part of another syndrome, but can have devastating developmental consequences. The events that break symmetry during early embryogenesis are highly conserved amongst vertebrates and involve the establishment of unidirectional flow by cilia within an organising centre such as the node in mammals or Kupffer's vesicle (KV) in teleosts. Disruption of this flow can lead to the failure to… CONTINUE READING
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