Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin.

@article{Nishimura2004Bbs2nullMH,
  title={Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin.},
  author={Darryl Y Nishimura and Melissa A. Fath and Robert F. Mullins and Charles C Searby and Michael P Andrews and Roger E Davis and Jeaneen Andorf and Kirk Mykytyn and Ruth E. Swiderski and Baoli Yang and Rivka Carmi and Edwin M. Stone and Val C. Sheffield},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 47},
  pages={16588-93}
}
Bardet-Biedl syndrome (BBS) is a heterogeneous, pleiotropic human disorder characterized by obesity, retinopathy, polydactyly, renal and cardiac malformations, learning disabilities, hypogenitalism, and an increased incidence of diabetes and hypertension. No information is available regarding the specific function of BBS2. We show that mice lacking Bbs2 gene expression have major components of the human phenotype, including obesity and retinopathy. In addition, these mice have phenotypes… CONTINUE READING
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Ph.D thesis (University of Paris, Paris)

  • G. Bardet
  • 1920

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