Bayesian search of functionally divergent protein subgroups and their function specific residues

@article{Marttinen2006BayesianSO,
  title={Bayesian search of functionally divergent protein subgroups and their function specific residues},
  author={Pekka Marttinen and Jukka Corander and Petri T{\"o}r{\"o}nen and Liisa Holm},
  journal={Bioinformatics},
  year={2006},
  volume={22 20},
  pages={2466-74}
}
MOTIVATION The rapid increase in the amount of protein sequence data has created a need for an automated identification of evolutionarily related subgroups from large datasets. The existing methods typically require a priori specification of the number of putative groups, which defines the resolution of the classification solution. RESULTS We introduce a Bayesian model-based approach to simultaneous identification of evolutionary groups and conserved parts of the protein sequences. The model… CONTINUE READING

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