Bayesian sample size determination for diagnostic accuracy studies

  title={Bayesian sample size determination for diagnostic accuracy studies},
  author={Kevin J. Wilson and S. Faye Williamson and A. Joy Allen and Cameron J Williams and Thomas P Hellyer and B Clare Lendrem},
  journal={Statistics in Medicine},
  pages={2908 - 2922}
The development of a new diagnostic test ideally follows a sequence of stages which, among other aims, evaluate technical performance. This includes an analytical validity study, a diagnostic accuracy study, and an interventional clinical utility study. In this article, we propose a novel Bayesian approach to sample size determination for the diagnostic accuracy study, which takes advantage of information available from the analytical validity stage. We utilize assurance to calculate the… 



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