Bayesian optimal designs for a quantal dose-response study with potentially missing observations.

  title={Bayesian optimal designs for a quantal dose-response study with potentially missing observations.},
  author={InYoung Baek and Wei Zhu and Xiangfeng Wu and Weng Kee Wong},
  journal={Journal of biopharmaceutical statistics},
  volume={16 5},
In a dose-response study, there are frequently multiple goals and not all planned observations are realized at the end of the study. Subjects drop out and the initial design can be quite different from the final design. Consequently, the final design can be inefficient. Single- and multiple-objective Bayesian optimal designs that account for potentially missing observations in quantal response models were recently proposed in Baek (2005). In this work, we investigate the efficiencies of the… CONTINUE READING

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