Bayesian methods for examining Hardy-Weinberg equilibrium.

  title={Bayesian methods for examining Hardy-Weinberg equilibrium.},
  author={Jonathan Wakefield},
  volume={66 1},
Testing for Hardy-Weinberg equilibrium is ubiquitous and has traditionally been carried out via frequentist approaches. However, the discreteness of the sample space means that uniformity of p-values under the null cannot be assumed, with enumeration of all possible counts, conditional on the minor allele count, offering a computationally expensive way of p-value calibration. In addition, the interpretation of the subsequent p-values, and choice of significance threshold depends critically on… CONTINUE READING
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Genetic Data Analysis II

  • B. Weir
  • Sunderland, Massachusetts: Sinauer.
  • 1996
Highly Influential
5 Excerpts

Compatible priors for Bayesian model comparison with an application to the Hardy-Weinberg equilibrium model

  • G. Consonni, E. Gutierrez-Pena, P. Veronese
  • Test 17, 585–605.
  • 2008
Highly Influential
3 Excerpts

Bayes factors

  • R. Kass, A. Raftery
  • Journal of the American Statistical Association…
  • 1995
Highly Influential
2 Excerpts

The Genetics of Human Populations

  • L. Cavalli-Sforza, W. Bodmer
  • San Francisco: W.H. Freeman and Company.
  • 1971
Highly Influential
1 Excerpt

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