Bayesian methods for examining Hardy-Weinberg equilibrium.

@article{Wakefield2010BayesianMF,
  title={Bayesian methods for examining Hardy-Weinberg equilibrium.},
  author={Jonathan Wakefield},
  journal={Biometrics},
  year={2010},
  volume={66 1},
  pages={257-65}
}
Testing for Hardy-Weinberg equilibrium is ubiquitous and has traditionally been carried out via frequentist approaches. However, the discreteness of the sample space means that uniformity of p-values under the null cannot be assumed, with enumeration of all possible counts, conditional on the minor allele count, offering a computationally expensive way of p-value calibration. In addition, the interpretation of the subsequent p-values, and choice of significance threshold depends critically on… CONTINUE READING
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