Bayesian inference on protective antibody levels using case-control data.

@article{Carey2001BayesianIO,
  title={Bayesian inference on protective antibody levels using case-control data.},
  author={Vincent J. Carey and Carol J. Baker and Robert Platt},
  journal={Biometrics},
  year={2001},
  volume={57 1},
  pages={135-42}
}
In the study of immune responses to infectious pathogens, the minimum protective antibody concentration (MPAC) is a quantity of great interest. We use case-control data to estimate the posterior distribution of the conditional risk of disease given a lower bound on antibody concentration in an at-risk subject. The concentration bound beyond which there is high credibility that infection risk is zero or nearly so is a candidate for the MPAC. A very simple Gibbs sampling procedure that permits… CONTINUE READING