Bayesian inference for randomized clinical trials with treatment failures.

@article{Shaffer2004BayesianIF,
  title={Bayesian inference for randomized clinical trials with treatment failures.},
  author={Michele L. Shaffer and Vernon M. Chinchilli},
  journal={Statistics in medicine},
  year={2004},
  volume={23 8},
  pages={
          1215-28
        }
}
During the course of a clinical trial, subjects may experience treatment failure. For ethical reasons, it is necessary to administer emergency or rescue medications for such subjects. However, the rescue medications may bias the set of response measurements. This bias is of particular concern if a subject has been randomized to the control group, and the rescue medications improve the subject's condition. The standard approach to analysing data from a clinical trial is to perform an intent-to… CONTINUE READING
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