Bayesian individualization of pharmacokinetics: simple implementation and comparison with non-Bayesian methods.

@article{Sheiner1982BayesianIO,
  title={Bayesian individualization of pharmacokinetics: simple implementation and comparison with non-Bayesian methods.},
  author={Lewis B. Sheiner and Stuart L. Beal},
  journal={Journal of pharmaceutical sciences},
  year={1982},
  volume={71 12},
  pages={
          1344-8
        }
}
One may attempt to individualize drug dosage by estimating an individual's pharmacokinetic parameters. Information useful for this purpose consists of certain population pharmacokinetic parameters (notably those describing the typical relationship between dosage and drug concentrations) and also measured drug concentrations from the individual of concern. Both types of information should be used. A (Bayesian) method that does so has been described in the pharmacokinetic literature. In this… CONTINUE READING

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