Bayesian gene/species tree reconciliation and orthology analysis using MCMC

@article{Arvestad2003BayesianGT,
  title={Bayesian gene/species tree reconciliation and orthology analysis using MCMC},
  author={Lars Arvestad and Ann-Charlotte Berglund Sonnhammer and Jens Lagergren and Bengt Sennblad},
  journal={Bioinformatics},
  year={2003},
  volume={19 Suppl 1},
  pages={i7-15}
}
MOTIVATION Comparative genomics in general and orthology analysis in particular are becoming increasingly important parts of gene function prediction. Previously, orthology analysis and reconciliation has been performed only with respect to the parsimony model. This discards many plausible solutions and sometimes precludes finding the correct one. In many other areas in bioinformatics probabilistic models have proven to be both more realistic and powerful than parsimony models. For instance… CONTINUE READING
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