Bayesian dose-finding in phase I/II clinical trials using toxicity and efficacy odds ratios.

Abstract

A Bayesian adaptive design is proposed for dose-finding in phase I/II clinical trials to incorporate the bivariate outcomes, toxicity and efficacy, of a new treatment. Without specifying any parametric functional form for the drug dose-response curve, we jointly model the bivariate binary data to account for the correlation between toxicity and efficacy… (More)

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Cite this paper

@article{Yin2006BayesianDI, title={Bayesian dose-finding in phase I/II clinical trials using toxicity and efficacy odds ratios.}, author={Guosheng Yin and Yisheng Li and Yuan Ji}, journal={Biometrics}, year={2006}, volume={62 3}, pages={777-84} }