Bayesian detection of abnormal values in longitudinal biomarkers with an application to T/E ratio.

@article{Sottas2007BayesianDO,
  title={Bayesian detection of abnormal values in longitudinal biomarkers with an application to T/E ratio.},
  author={P E Sottas and Norbert Baume and Christophe Saudan and Carine Schweizer and Matthias Kamber and Martial Saugy},
  journal={Biostatistics},
  year={2007},
  volume={8 2},
  pages={285-96}
}
We developed a test that compares sequential measurements of a biomarker against previous readings performed on the same individual. A probability mass function expresses prior information on interindividual variations of intraindividual parameters. Then, the model progressively integrates new readings to more accurately quantify the characteristics of the individual. This Bayesian framework generalizes the two main approaches currently used in forensic toxicology for the detection of abnormal… CONTINUE READING
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