Bayesian Spatial Modeling of Haplotype Associations

@article{Thomas2003BayesianSM,
  title={Bayesian Spatial Modeling of Haplotype Associations},
  author={Duncan C Thomas and Daniel O. Stram and David V. Conti and John Molitor and P. Marjoram},
  journal={Human Heredity},
  year={2003},
  volume={56},
  pages={32 - 40}
}
We review methods for relating the risk of disease to a collection of single nucleotide polymorphisms (SNPs) within a small region. Association studies using case-control designs with unrelated individuals could be used either to test for a direct effect of a candidate gene and characterize the responsible variant(s), or to fine map an unknown gene by exploiting the pattern of linkage disequilibrium (LD). We consider a flexible class of logistic penetrance models based on haplotypes and compare… CONTINUE READING

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