Bayesian Estimates of the Evolutionary Rate and Age of Hepatitis B Virus

  title={Bayesian Estimates of the Evolutionary Rate and Age of Hepatitis B Virus},
  author={Yang Zhou and Edward C. Holmes},
  journal={Journal of Molecular Evolution},
Accurately estimating the evolutionary rate and age of hepatitis B virus (HBV) has proven to be one of the most difficult problems in studies of viral evolution. To help resolve these issues we employed a recently developed Bayesian coalescent approach to globally sampled human and avian hepadnavirus genome sequences, accounting for lineage-specific rate variation, the presence of overlapping reading frames, and the potential impact of recombination. Our analysis revealed an unexpectedly high… 
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  • P. Simmonds
  • Biology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2001
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