Bayesian Dose-Finding in Two Treatment Cycles Based on the Joint Utility of Efficacy and Toxicity.

@article{Lee2015BayesianDI,
  title={Bayesian Dose-Finding in Two Treatment Cycles Based on the Joint Utility of Efficacy and Toxicity.},
  author={Juhee Lee and Peter F. Thall and Yuan Ji and Peter Mueller},
  journal={Journal of the American Statistical Association},
  year={2015},
  volume={110 510},
  pages={
          711-722
        }
}
A phase I/II clinical trial design is proposed for adaptively and dynamically optimizing each patient's dose in each of two cycles of therapy based on the joint binary efficacy and toxicity outcomes in each cycle. A dose-outcome model is assumed that includes a Bayesian hierarchical latent variable structure to induce association among the outcomes and also facilitate posterior computation. Doses are chosen in each cycle based on posteriors of a model-based objective function, similar to a… CONTINUE READING