Bayesian Adaptive Designs for Early Phase Clinical Trials

  title={Bayesian Adaptive Designs for Early Phase Clinical Trials},
  author={Chunyan Cai},
BAYESIAN ADAPTIVE DESIGNS FOR EARLY PHASE CLINICAL TRIALS Publication No. Chunyan Cai, B.S. Supervisory Professor: Ying Yuan, Ph.D. My dissertation focuses mainly on Bayesian adaptive designs for phase I and phase II clinical trials. It includes three specific topics: (1) proposing a novel two-dimensional dose-finding algorithm for biological agents, (2) developing Bayesian adaptive screening designs to provide more efficient and ethical clinical trials, and (3) incorporating missing late-onset… CONTINUE READING