Bayes factors in complex genetics

@article{Sawcer2010BayesFI,
  title={Bayes factors in complex genetics},
  author={Stephen J Sawcer},
  journal={European Journal of Human Genetics},
  year={2010},
  volume={18},
  pages={746-750}
}
The past few years have seen tremendous progress in our understanding of the genetics underlying complex disease, with associated variants being identified in dozens of traits. Despite the fact that this growing body of empirical evidence unequivocally shows the necessity for extreme levels of significance and large samples sizes, the reasoning behind these requirements is not always appreciated. As genome-wide association studies reach the limits of their resolution in the search for rarer and… CONTINUE READING
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Genome - wide association study of 14 , 000 cases of seven common diseases and 3 , 000 shared controls

  • MA Hauser, YJ Li, S Takeuchi
  • Nature
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