Bax inhibitor 1 increases cell adhesion through actin polymerization: involvement of calcium and actin binding.

@article{Lee2010BaxI1,
  title={Bax inhibitor 1 increases cell adhesion through actin polymerization: involvement of calcium and actin binding.},
  author={G Lee and Taeho Ahn and Do-Sung Kim and Seoung Ju Park and Yong Chul Lee and Wan Hee Yoo and Sung Jun Jung and J Yang and Sanguk Kim and Andras Muhlrad and Young-Rok Seo and Soo-wan Chae and Hyung-ryong Kim and Han-jung Chae},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 7},
  pages={1800-13}
}
Bax inhibitor 1 (BI-1), a transmembrane protein with Ca2+ channel-like activity, has antiapoptotic and anticancer activities. Cells overexpressing BI-1 demonstrated increased cell adhesion. Using a proteomics tool, we found that BI-1 interacted with gamma-actin via leucines 221 and 225 and could control actin polymerization and cell adhesion. Among BI-1-/- cells and cells transfected with BI-1 small interfering RNA (siRNA), levels of actin polymerization and cell adhesion were lower than those… CONTINUE READING
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