Bax does not directly participate in the Ca(2+)-induced permeability transition of isolated mitochondria.

@article{Marchi2004BaxDN,
  title={Bax does not directly participate in the Ca(2+)-induced permeability transition of isolated mitochondria.},
  author={Umberto De Marchi and Silvia Campello and Ildik{\`o} Szab{\`o} and Francesco Tombola and J C Martinou and Mario Zoratti},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 36},
  pages={37415-22}
}
The mitochondrial permeability transition pore and Bax have both been proposed to be involved in the release of pro-apoptotic factors from mitochondria in the "intrinsic" pathway of apoptosis. The permeability transition pore is widely thought to be a supramolecular complex including or interacting with Bax. Given the relevance of the permeability transition in vivo, we have verified whether Bax influences the formation and/or the properties of the Ca(2+)/P(i)-induced permeability transition by… CONTINUE READING

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