Bax deficiency affects caspase-2 activation during ultraviolet radiation-induced apoptosis

@article{He2004BaxDA,
  title={Bax deficiency affects caspase-2 activation during ultraviolet radiation-induced apoptosis},
  author={Qin He and Ying Huang and Muhammed S Sheikh},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={1321-1325}
}
There has been a considerable debate as to whether caspase-2 is an initiator or effector caspase. Recently, a new model of intrinsic pathway of apoptosis has been proposed, which suggests caspase-2 to be an initiator caspase. For example, ultraviolet radiation (UV) and other DNA damage-inducing agents were shown to first activate caspase-2 and then regulate… CONTINUE READING