Bax antisense oligonucleotides reduce axotomy-induced retinal ganglion cell death in vivo by reduction of Bax protein expression

@article{Isenmann1999BaxAO,
  title={Bax antisense oligonucleotides reduce axotomy-induced retinal ganglion cell death in vivo by reduction of Bax protein expression},
  author={Stefan Isenmann and Stefan Engel and Frank Gillardon and Mathias B{\"a}hr},
  journal={Cell Death and Differentiation},
  year={1999},
  volume={6},
  pages={673-682}
}
Following transection of the optic nerve (ON), retinal ganglion cells (RGCs) upregulate Bax protein expression and undergo apoptosis. The present study aimed at reducing Bax expression in order to test whether Bax plays a causative role in the induction of secondary RGC apoptosis. Following injection into the vitreous, fluoresceinated oligonucleotides transfected RGCs in vivo at the injection site in the temporal superior retina. Following ON lesion, and repeated injections of a partially… CONTINUE READING