• Biology, Medicine
  • Published in
    Frontiers in bioscience : a…
    2002
  • DOI:10.2741/a772

Bax and BH3-domain-only proteins in p53-mediated apoptosis.

@article{Wu2002BaxAB,
  title={Bax and BH3-domain-only proteins in p53-mediated apoptosis.},
  author={Xiangwei Wu and Yibin Deng},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2002},
  volume={7},
  pages={
          d151-6
        }
}
Activation of mitochondria-mediated apoptosis represents a major anti-tumor response of p53. One of the mechanisms for p53 to induce mitochondria-mediated cell death events is to activate genes that are directly involved in the initiation of mitochondria-induced apoptosis. Among them are Bcl-2 family members, Noxa, PUMA, and Bax. They have been shown to be direct targets in p53-mediated apoptosis. The Bax protein belongs to the multidomain Bcl-2 family, while Noxa and PUMA are BH3-domain-only… CONTINUE READING

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