Bax affects intracellular Ca2+ stores and induces Ca2+ wave propagation

  title={Bax affects intracellular Ca2+ stores and induces Ca2+ wave propagation},
  author={Ars{\'e}lio Pato Carvalho and James Sharpe and Tatiana R Rosenstock and A V F F Teles and Alicia J Kowaltowski and Richard J Youle and Soraya Shoubi Smaili},
  journal={Cell Death and Differentiation},
AbstractIn the present study, we evaluated proapoptotic protein Bax on mitochondria and Ca2+ homeostasis in primary cultured astrocytes. We found that recombinant Bax (rBax, 10 and 100 ng/ml) induces a loss in mitochondrial membrane potential (ΔΨm). This effect might be related to the inhibition of respiratory rates and a partial release of cytochrome c, which may change mitochondrial morphology. The loss of ΔΨm and a selective permeabilization of mitochondrial membranes contribute to the… CONTINUE READING


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