Bax activation by Bim?

  title={Bax activation by Bim?},
  author={Peter E. Czabotar and Peter M. Colman and David C S Huang},
  journal={Cell Death and Differentiation},
The mechanism by which the cell death mediator Bax becomes activated to cause mitochondrial damage, a key step for the intrinsic pathway to apoptosis, remain highly contentious. Although some data support a role for certain BH3-only proteins, such as Bim or tBid, to directly activate Bax, others have led to the conclusion that BH3-only proteins act indirectly by antagonizing the prosurvival Bcl-2 proteins, thereby allowing Bax activation to proceed. A recent paper in Nature by Gavathiotis et al… CONTINUE READING