Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming

@inproceedings{Schellenberg2013BaxEI,
  title={Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming},
  author={Barbara Schellenberg and Pengbo Wang and James A. Keeble and Ricardo Rodriguez-Enriquez and Scott C. Walker and Thomas W. Owens and Fiona M. Foster and Jolanta Tanianis-Hughes and Keith Brennan and Charles H Streuli and Andrew P Gilmore},
  booktitle={Molecular cell},
  year={2013}
}
The proapoptotic Bcl-2 protein Bax is predominantly found in the cytosol of nonapoptotic cells and is commonly thought to translocate to mitochondria following an apoptotic stimulus. The current model for Bax activation is that BH3 proteins bind to cytosolic Bax, initiating mitochondrial targeting and outer-membrane permeabilization. Here, we challenge this and show that Bax is constitutively targeted to mitochondria but in nonapoptotic cells is constantly translocated back to the cytosol… CONTINUE READING
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