Bax/Bak activation in the absence of Bid, Bim, Puma, and p53

@inproceedings{Zhang2016BaxBakAI,
  title={Bax/Bak activation in the absence of Bid, Bim, Puma, and p53},
  author={Jun Zhang and Katherine Huang and Kim L O'Neill and X Pang and X Luo},
  booktitle={Cell Death and Disease},
  year={2016}
}
How BH3-only proteins activate Bax/Bak, the two gateway proteins of the mitochondria-dependent apoptotic pathway, remains incompletely understood. Although all pro-apoptotic BH3-only proteins are known to bind/neutralize the anti-apoptotic Bcl-2 proteins, the three most potent ones, Bid (tBid), Bim, and Puma, possess an additional activity of directly activating Bax/Bak in vitro. This latter activity has been proposed to be responsible for triggering Bax/Bak activation following apoptotic… CONTINUE READING
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