Battle of the hemichannels – Connexins and Pannexins in ischemic brain injury

  title={Battle of the hemichannels – Connexins and Pannexins in ischemic brain injury},
  author={Joanne O Davidson and Colin Richard Green and Laura Bennet and Alistair J. Gunn},
  journal={International Journal of Developmental Neuroscience},
Perinatal ischemic brain injury can occur as a result of a global ischemic insult or focal ischemic stroke in the preterm or full-term neonate. One of the most striking features of HI injury is that, after initial recovery of cellular oxidative metabolism, there is a delayed, 'secondary' mitochondrial failure that spreads over time from the most severely damaged areas outwards, into previously undamaged regions. This secondary failure is accompanied by transient seizure activity and cytotoxic… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 11 extracted citations

Non-additive effects of delayed connexin hemichannel blockade and hypothermia after cerebral ischemia in near-term fetal sheep.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2015

Similar Papers

Loading similar papers…