Battle of the hemichannels – Connexins and Pannexins in ischemic brain injury

@article{Davidson2015BattleOT,
  title={Battle of the hemichannels – Connexins and Pannexins in ischemic brain injury},
  author={Joanne O Davidson and Colin Richard Green and Laura Bennet and Alistair J. Gunn},
  journal={International Journal of Developmental Neuroscience},
  year={2015},
  volume={45},
  pages={66-74}
}
Perinatal ischemic brain injury can occur as a result of a global ischemic insult or focal ischemic stroke in the preterm or full-term neonate. One of the most striking features of HI injury is that, after initial recovery of cellular oxidative metabolism, there is a delayed, 'secondary' mitochondrial failure that spreads over time from the most severely damaged areas outwards, into previously undamaged regions. This secondary failure is accompanied by transient seizure activity and cytotoxic… CONTINUE READING

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Non-additive effects of delayed connexin hemichannel blockade and hypothermia after cerebral ischemia in near-term fetal sheep.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2015

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