Battle for the EF-hands: magnesium-calcium interference in calmodulin.

  title={Battle for the EF-hands: magnesium-calcium interference in calmodulin.},
  author={Anders Malmendal and Sara Linse and Johan Even{\"a}s and Sture Fors{\'e}n and Torbjorn Drakenberg},
  volume={38 36},
The ubiquitous Ca(2+)-regulatory protein calmodulin activates target enzymes as a response to submicromolar Ca(2+) increases in a background of millimolar Mg(2+). The potential influence of Mg(2+)/Ca(2+) competition is especially intriguing for the N-terminal domain of the protein which possesses the sites with the lowest Ca(2+) specificity. The interdependence of Ca(2+) and Mg(2+) binding in the N-terminal domain of calmodulin was therefore studied using (43)Ca NMR, (1)H-(15)N NMR, and… CONTINUE READING

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