Battle for the EF-hands: magnesium-calcium interference in calmodulin.

@article{Malmendal1999BattleFT,
  title={Battle for the EF-hands: magnesium-calcium interference in calmodulin.},
  author={Anders Malmendal and Sara Linse and Johan Even{\"a}s and Sture Fors{\'e}n and Torbjorn Drakenberg},
  journal={Biochemistry},
  year={1999},
  volume={38 36},
  pages={
          11844-50
        }
}
The ubiquitous Ca(2+)-regulatory protein calmodulin activates target enzymes as a response to submicromolar Ca(2+) increases in a background of millimolar Mg(2+). The potential influence of Mg(2+)/Ca(2+) competition is especially intriguing for the N-terminal domain of the protein which possesses the sites with the lowest Ca(2+) specificity. The interdependence of Ca(2+) and Mg(2+) binding in the N-terminal domain of calmodulin was therefore studied using (43)Ca NMR, (1)H-(15)N NMR, and… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 23 CITATIONS

The use of ESI-MS to probe the binding of divalent cations to calmodulin

  • Journal of the American Society for Mass Spectrometry
  • 2009
VIEW 6 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Inseparable tandem: evolution chooses ATP and Ca2+ to control life, death and cellular signalling.

  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2016