Batch and fed-batch production of coenzyme Q10 in recombinant Escherichia coli containing the decaprenyl diphosphate synthase gene from Gluconobacter suboxydans

@article{Park2004BatchAF,
  title={Batch and fed-batch production of coenzyme Q10 in recombinant Escherichia coli containing the decaprenyl diphosphate synthase gene from Gluconobacter suboxydans},
  author={Yong-cheol Park and Soo-Jung Kim and Jin Ho Choi and Won-Heong Lee and Kyung-Moon Park and Mokoto Kawamukai and Yeon-woo Ryu and Jin-Ho Seo},
  journal={Applied Microbiology and Biotechnology},
  year={2004},
  volume={67},
  pages={192-196}
}
Coenzyme Q10 (CoQ10) is a quinine consisting of ten units of the isoprenoid side-chain. Because it limits the oxidative attack of free radicals to DNA and lipids, CoQ10 has been used as an antioxidant for foods, cosmetics and pharmaceuticals. Decaprenyl diphosphate synthase (DPS) is the key enzyme for synthesis of the decaprenyl tail in CoQ10 with isopentenyl diphosphate. The ddsA gene coding for DPS from Gluconobacter suboxydans was expressed under the control of an Escherichia coli… CONTINUE READING
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