Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases.

Abstract

The methyltransferase DOT1L methylates histone H3 at K79 to facilitate specific biological events. H3K79 dimethylation (H3K79-2Me) by DOT1L influences the DNA damage response by promoting 53BP1 recruitment to DNA damage sites; however, it is unclear if this methylation is required as 53BP1 interacts with dimethylated H4 (H4K20-2Me) with a much higher… (More)
DOI: 10.1038/emboj.2012.50

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@article{Wakeman2012Bat3FH, title={Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases.}, author={Timothy P. Wakeman and Qin-hong Wang and Junjie Feng and Xiaofan Wang}, journal={The EMBO journal}, year={2012}, volume={31 9}, pages={2169-81} }