Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis

  title={Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis},
  author={Toru Sasaki and Edyta Marcon and Tracy A. McQuire and Yoichi Arai and Peter B. Moens and Hitoshi Okada},
  journal={The Journal of Cell Biology},
  pages={449 - 458}
Meiosis is critical for sexual reproduction. During meiosis, the dynamics and integrity of homologous chromosomes are tightly regulated. The genetic and molecular mechanisms governing these processes in vivo, however, remain largely unknown. In this study, we demonstrate that Bat3/Scythe is essential for survival and maintenance of male germ cells (GCs). Targeted inactivation of Bat3/Scythe in mice results in widespread apoptosis of meiotic male GCs and complete male infertility. Pachytene… CONTINUE READING
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