Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26.

@article{Wang2014BatOO,
  title={Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26.},
  author={Qihui Wang and Jianxun Qi and Yuan Yuan and Yifang Xuan and Pengcheng Han and Yuhua Wan and Wei Ji and Yan Su Li and Yan Yan Wu and Jianwei Wang and Aikichi Iwamoto and Patrick C. Y. Woo and Kwok - Yung Yuen and Jinghua Yan and Guangwen Lu and George F. Gao},
  journal={Cell host & microbe},
  year={2014},
  volume={16 3},
  pages={328-37}
}
The recently reported Middle East respiratory syndrome coronavirus (MERS-CoV) is phylogenetically closely related to the bat coronaviruses (BatCoVs) HKU4 and HKU5. However, the evolutionary pathway of MERS-CoV is still unclear. A receptor binding domain (RBD) in the MERS-CoV envelope-embedded spike protein specifically engages human CD26 (hCD26) to initiate viral entry. The high sequence identity in the viral spike protein prompted us to investigate if HKU4 and HKU5 can recognize hCD26 for cell… CONTINUE READING
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