Bat influenza viruses transmit among bats but are poorly adapted to non-bat species

  title={Bat influenza viruses transmit among bats but are poorly adapted to non-bat species},
  author={Kevin Ciminski and Wei Ran and Marco Gorka and Jinhwa Lee and Ashley Malmlov and Jan Schink{\"o}the and Miles Eckley and Reyes A. Murrieta and Tawfik A Aboellail and Corey L Campbell and Gregory D. Ebel and Jingjiao Ma and Anne Pohlmann and Kati Franzke and Reiner Ulrich and Donata Hoffmann and Adolfo Garc{\'i}a-Sastre and Wenjun Ma and Tony Schountz and Martin Beer and Martin Schwemmle},
  journal={Nature Microbiology},
Major histocompatibility complex class II (MHC-II) molecules of multiple species function as cell-entry receptors for the haemagglutinin-like H18 protein of the bat H18N11 influenza A virus, enabling tropism of the viruses in a potentially broad range of vertebrates. However, the function of the neuraminidase-like N11 protein is unknown because it is dispensable for viral infection or the release of H18-pseudotyped viruses. Here, we show that infection of mammalian cells with wild-type H18N11… Expand
Mutations in the Neuraminidase-Like Protein of Bat Influenza H18N11 Virus Enhance Virus Replication in Mammalian Cells, Mice, and Ferrets
The characterization of artificially generated bat influenza H18N11 virus in mammalian cell lines and animal models revealed that this virus can acquire mammal-adapting mutations that may increase its zoonotic potential; however, the wild-type and mutant viruses did not replicate to high titers in all infected animals. Expand
A species-specific signature residue in the PB2 subunit of the bat influenza virus polymerase restricts viral RNA synthesis
This work identifies novel species-specific signatures present within the influenza virus polymerase that may serve as a key factor in the adaptation of influenza viruses from bat to non-bat host species and vice versa. Expand
Bats reveal the true power of influenza A virus adaptability
The discovery of influenza viruses in New and Old World bats did severely challenge previous conception of IAV host range and phylogeny and provided unexpected insights into the remarkable adaptive potential of these viruses and their evolutionary origin. Expand
Bat-Borne Influenza A Viruses: An Awakening.
This review recapitulates current progress in the field of bat IAV research including the first assessment of the spillover potential of these bat viruses into other mammals. Expand
Host Receptors of Influenza Viruses and Coronaviruses—Molecular Mechanisms of Recognition
The structures, diversities, host ranges and host receptors of all IVs and CoVs are overviewed and current knowledge of receptor binding specificity of spike glycoproteins is critically reviewed to develop efficient strategies for controlling virus outbreaks and recurrences of seasonal virus variants. Expand
Replication and virulence of chimeric bat influenza viruses in mammalian and avian cells and in mice.
This study indicates that bat influenzainternal genes are permissive in both mammalian and avian cells, and the bat influenza internal M gene shows more compatibility in mammals than in the avian host. Expand
Inferring the Urban Transmission Potential of Bat Influenza Viruses
  • E. S. Giotis
  • Medicine, Biology
  • Frontiers in Cellular and Infection Microbiology
  • 2020
Delineating the mechanistic basis of the interactions with their hosts and assessing their global distribution are essential in order to fully assess the zoonotic threat that these strains pose. Expand
Egyptian Fruit Bats (Rousettus aegyptiacus) Were Resistant to Experimental Inoculation with Avian-Origin Influenza A Virus of Subtype H9N2, But Are Susceptible to Experimental Infection with Bat-Borne H9N2 Virus
Egyptian fruit bats are most likely not susceptible to the avian H9N2 subtype, but can be infected with fruit bat-derived H7N9 viruses, and H9-specific sero-reactivities in fruit bats in the field are more likely the result of contact with a bat-adapted H8N2 strain. Expand
Influenza A (N1-N9) and Influenza B (B/Vic and B/Yam) Neuraminidase Pseudotypes as Tools for Pandemic Preparedness and Improved Influenza Vaccine design
To better understand how inhibition of the influenza neuraminidase (NA) protein contributes to protection against influenza, and to investigate its breadth and cross-neutralizing activity, we haveExpand
Bat Influenza Viruses: Current Status and Perspective
Current status and perspective on influenza A viruses identified in bats is reviewed and discussed and an H9N2-like influenza A virus was isolated from Old World bats and it shows similar characteristics of normal influenza A diseases. Expand


MHC class II proteins mediate cross-species entry of bat influenza viruses
The DR isotype of the human leukocyte antigen of the MHC class II—or its homologues in bats, pigs, mice and chickens—is an essential cell entry determinant for bat influenza A viruses. Expand
An infectious bat-derived chimeric influenza virus harbouring the entry machinery of an influenza A virus
The generation of an infectious chimeric virus containing six out of the eight bat virus genes, with the remaining two genes encoding the haemagglutinin and neuraminidase proteins of a prototypic influenza A virus, indicates that multiple barriers exist that makes this an unlikely event. Expand
New World Bats Harbor Diverse Influenza A Viruses
Using consensus degenerate RT-PCR, a novel influenza A virus is identified in a flat-faced fruit bat from Peru, indicating that bats constitute a potentially important and likely ancient reservoir for a diverse pool of influenza viruses. Expand
Synthetically derived bat influenza A-like viruses reveal a cell type- but not species-specific tropism
Recombinant vesicular stomatitis virus (VSV) encoding the hemagglutinin-like envelope glycoproteins HL17 or HL18 in place of the VSV glycoprotein were generated to identify cell lines that are susceptible to bat influenza A-like virus entry. Expand
Characterization of the glycoproteins of bat-derived influenza viruses
It is found that VSVs pseudotyped with BatIV HAs and NAs efficiently infected particular bat cell lines but not those derived from primates, and that proteolytic cleavage with a trypsin-like protease was necessary for HA-mediated virus entry. Expand
Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans
Generation of Swine Flu As the newly emerged influenza virus starts its journey to infect the world's human population, the genetic secrets of the 2009 outbreak of swine influenza A(H1N1) are beingExpand
Experimental adaptation of an influenza H5 haemagglutinin (HA) confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets
Results indicate that H5 HA can convert to an HA that supports efficient viral transmission in mammals, and will help individuals conducting surveillance in regions with circulating H5N1 viruses to recognize key residues that predict the pandemic potential of isolate, which will inform the development, production and distribution of effective countermeasures. Expand
A distinct lineage of influenza A virus from bats
  • S. Tong, Y. Li, +23 authors R. Donis
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2012
Despite its divergence from known influenza A virus, the bat virus is compatible for genetic exchange with human influenza viruses in human cells, suggesting the potential capability for reassortment and contributions to new pandemic or panzootic influenza A viruses. Expand
Bat-derived influenza hemagglutinin H17 does not bind canonical avian or human receptors and most likely uses a unique entry mechanism.
It is demonstrated that H17 is unique among characterized HAs and that the bat-derived influenza virus may use a different entry mechanism compared to canonical influenza viruses. Expand
Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets
Avian A/H5N1 influenza viruses can acquire the capacity for airborne transmission between mammals without recombination in an intermediate host and therefore constitute a risk for human pandemic influenza. Expand