Bat influenza viruses transmit among bats but are poorly adapted to non-bat species

@article{Ciminski2019BatIV,
  title={Bat influenza viruses transmit among bats but are poorly adapted to non-bat species},
  author={Kevin Ciminski and Wei Ran and Marco Gorka and Jinhwa Lee and A. Malmlov and J. Schinkoethe and Miles Eckley and Reyes A. Murrieta and T. Aboellail and C. Campbell and G. Ebel and J. Ma and A. Pohlmann and K. Franzke and R. Ulrich and D. Hoffmann and A. Garc{\'i}a-Sastre and W. Ma and T. Schountz and M. Beer and M. Schwemmle},
  journal={Nature Microbiology},
  year={2019},
  volume={4},
  pages={2298-2309}
}
  • Kevin Ciminski, Wei Ran, +18 authors M. Schwemmle
  • Published 2019
  • Biology, Medicine
  • Nature Microbiology
  • Major histocompatibility complex class II (MHC-II) molecules of multiple species function as cell-entry receptors for the haemagglutinin-like H18 protein of the bat H18N11 influenza A virus, enabling tropism of the viruses in a potentially broad range of vertebrates. However, the function of the neuraminidase-like N11 protein is unknown because it is dispensable for viral infection or the release of H18-pseudotyped viruses. Here, we show that infection of mammalian cells with wild-type H18N11… CONTINUE READING
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