Bat coronaviruses related to SARS-CoV-2 and infectious for human cells.

  title={Bat coronaviruses related to SARS-CoV-2 and infectious for human cells.},
  author={Sarah Temmam and Khamsing Vongphayloth and E Salazar and Sandie Munier and Massimiliano Bonomi and B{\'e}atrice Regnault and Bounsavane Douangboubpha and Yasaman Karami and Delphine Chr{\'e}tien and Daosavanh Sanamxay and Vilakhan Xayaphet and Phetphoumin Paphaphanh and Vincent Lacoste and Somphavanh Somlor and Khaithong Lakeomany and Nothasin Phommavanh and Philippe P{\'e}rot and Oc{\'e}ane Dehan and Faustine Amara and Flora Donati and Thomas Bigot and Michael Nilges and F{\'e}lix A. Rey and Sylvie van der Werf and Paul T. Brey and Marc Eloit},
The animal reservoir of SARS-CoV-2 is unknown despite reports of various SARS-CoV-2-related viruses in Asian Rhinolophus bats1-4, including the closest virus from R. affinis, RaTG135,6 and in pangolins7-9. SARS-CoV-2 presents a mosaic genome, to which different progenitors contribute. The spike sequence determines the binding affinity and accessibility of its receptor-binding domain (RBD) to the cellular angiotensin-converting enzyme 2 (ACE2) receptor and is responsible for host range10-12… 
Bat coronaviruses related to SARS-CoV-2: what about their 3CL proteases (MPro)?
The similarities and differences between the 3CL protease (main protease, Mpro) of these newly reported viruses and SARS-CoV-2 are analysed, discussing their relevance relative to the efficacy of existing therapeutic approaches against COVID-19, particularly concerning the recently approved orally available Paxlovid, and the development of future ones.
Species-Specific Molecular Barriers to SARS-CoV-2 Replication in Bat Cells
This work has generated primary cells and cell lines from several bat species that are relevant for coronavirus research and highlights the existence of species-specific and cell-specific molecular barriers to viral replication in bat cells.
Isolation of bat sarbecoviruses of SARS-CoV-2 clade, Japan
Several bat sarbecoviruses of the SARS-CoV-2 clade from R. cornutus are detected in multiple locations in Japan, and successfully isolated them using Vero/TMPRSS2 cells stably expressing R.Cornutus ACE2 (Vero-RcACE2).
Distinct evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates identify important host determinants of COVID-19
Functional adaptations involved in SARS- CoV-2 infection in bats and primates are identified, critically enlightening modern genetic determinants of virus susceptibility and severity.
Inactivated SARS-CoV-2 Vaccine Shows Cross-Protection against Bat SARS-Related Coronaviruses in Human ACE2 Transgenic Mice
The protective efficacy of the SARS-CoV-2 inactivated vaccine (IAV) against two SARSr-CoVs with different spike proteins in human ACE2 transgenic mice is tested and suggests the feasibility of the development of pan-sarbecovirus vaccines, which can be a strategy of preparedness for future outbreaks caused by novel Sarsr- CoVs from wildlife.
Evidence for yeast artificial synthesis in SARS-CoV-2 and SARS-CoV-1 genomic sequences
Evidence is provided that among SARS-like coronaviruses only the genomes of SARS-CoV-1 and SARs- coV-2 contain information that points to a synthetic passage in genetically modified yeast cells.
The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2.
It is shown that SARS-CoV-2 genomic diversity before February 2020 likely comprised only two distinct viral lineages, denoted A and B, and that these lineages were the result of at least two separate cross-species transmission events into humans.
A First Assessment of SARS-CoV-2 Circulation in Bats of Central–Southern Italy
One serious concern associated with the SARS-CoV-2 pandemic is that the virus might spill back from humans to wildlife, which would render some animal species reservoirs of the human virus. We
The Finding of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) in a Wild Eurasian River Otter (Lutra lutra) Highlights the Need for Viral Surveillance in Wild Mustelids
Evidence of spillover infection of wild mustelids by reporting the presence of SARS-CoV-2 in a Eurasian river otter found near a water reservoir in the Valencian Community (Spain) is presented.
Coronaviruses in wild animals sampled in and around Wuhan at the beginning of COVID-19 emergence
More scientific efforts are warranted to better understand the high circulation of CCoVs in raccoon dogs in China and the possibility of a potential human agent.