Basophils are inept at promoting human Th17 responses.

  title={Basophils are inept at promoting human Th17 responses.},
  author={Meenu Sharma and Emmanuel Stephen-Victor and Pascal Poncet and Srini V Kaveri and Jagadeesh Bayry},
  journal={Human immunology},
  volume={76 2-3},
Basophils are the rare granulocytes and play an important role in the polarization of Th2 responses and protection against helminth parasites. In addition, basophils contribute to the pathogenesis of several diseases such as asthma, chronic allergy and lupus. Notably, Th17 cells are also implicated in the pathogenesis of these diseases suggesting that basophils support the activation and expansion of this subset of CD4(+) T cells. Therefore, we explored whether basophils promote the expansion… CONTINUE READING
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