Basolateral proteinase-activated receptor (PAR-2) induces chloride secretion in M-1 mouse renal cortical collecting duct cells.

@article{Bertog1999BasolateralPR,
  title={Basolateral proteinase-activated receptor (PAR-2) induces chloride secretion in M-1 mouse renal cortical collecting duct cells.},
  author={Marko Bertog and B. Letz and Wei-jia Kong and Martin S Steinhoff and Marnie A. Higgins and Andreas Bielfeld-Ackermann and Eberhard Fr{\"o}mter and Nigel W Bunnett and Christoph Korbmacher},
  journal={The Journal of physiology},
  year={1999},
  volume={521 Pt 1},
  pages={3-17}
}
1. Using RT-PCR, Northern blot analysis, and immunocytochemistry, we confirmed renal expression of proteinase-activated receptor (PAR-2) and demonstrated its presence in native renal epithelial and in cultured M-1 mouse cortical collecting duct (CCD) cells. 2. We investigated the effects of a PAR-2 activating peptide (AP), corresponding to the tethered ligand that is exposed upon trypsin cleavage, and of trypsin on M-1 cells using patch-clamp, intracellular calcium (fura-2) and transepithelial… CONTINUE READING
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