Basolateral active uptake of nitrofurantoin in the CIT3 cell culture model of lactation.

@article{Gerk2003BasolateralAU,
  title={Basolateral active uptake of nitrofurantoin in the CIT3 cell culture model of lactation.},
  author={P. Gerk and J. Moscow and P. McNamara},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2003},
  volume={31 6},
  pages={
          691-3
        }
}
Nitrofurantoin and other agents are actively transported into human and rodent milk. The purpose of this study was to determine whether nitrofurantoin active transport across mammary epithelia occurs basolaterally or apically, using the CIT3 cell culture model of lactation. The CIT3 model actively transports nitrofurantoin in the basolateral to apical direction. Basolateral to apical permeability [92.9 +/- 6.6 (microl/h)/cm(2)] was differentially decreased by unlabeled nitrofurantoin (250… Expand
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References

SHOWING 1-10 OF 12 REFERENCES
Active transport of nitrofurantoin across a mouse mammary epithelial monolayer.
  • 37
Interactions between cimetidine, nitrofurantoin, and probenecid active transport into rat milk.
  • 49
  • PDF
Sodium Dependence of Nitrofurantoin Active Transport Across Mammary Epithelia and Effects of Dipyridamole, Nucleosides, and Nucleobases
  • 15
Transport of ochratoxin A by renal multispecific organic anion transporter 1.
  • 99
  • PDF
Nitrofurantoin produces oxidative stress and loss of glutathione and protein thiols in the isolated perfused rat liver.
  • 33
  • Highly Influential
In vivo evaluation in the lactating rabbit of a model for xenobiotic distribution into breast milk.
  • 36
Mechanism of nitrofurantoin toxicity and oxidative stress in mitochondria.
  • 20
  • Highly Influential
Nitrofurantoin-induced pulmonary toxicity. In vivo evidence for oxidative stress-mediated mechanisms.
  • 40
Bile salt transporters.
  • 505
Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters.
  • 263
...
1
2
...