Basolateral Na+-H+ exchanger-1 in rat taste receptor cells is involved in neural adaptation to acidic stimuli.

@article{Lyall2004BasolateralNE,
  title={Basolateral Na+-H+ exchanger-1 in rat taste receptor cells is involved in neural adaptation to acidic stimuli.},
  author={Vijay Lyall and Rammy I. Alam and Shahbaz A. Malik and T Phan and Anna K. Vinnikova and Gerard L. Heck and John A Desimone},
  journal={The Journal of physiology},
  year={2004},
  volume={556 Pt 1},
  pages={159-73}
}
The role of basolateral Na(+)-H(+) exchanger isoform-1 (NHE-1) was investigated in neural adaptation of rat taste responses to acidic stimuli, by direct measurement of intracellular pH (pH(i)) in polarized taste receptor cells (TRCs) and by chorda tympani (CT) taste nerve recordings. In TRCs perfused with CO(2)/HCO(3)(-)-free solution (pH 7.4), removal of basolateral Na(+) decreased pH(i) reversibly and zoniporide, a specific NHE-1 blocker, inhibited the Na(+)-induced changes in pH(i). The… CONTINUE READING